Structural load challenges during space shuttle development

The challenges that resulted from the unique configuration of the space shuttle and capabilities developed to meet these challenges are described. The methods and the organization that were developed to perform dynamic loads analyses on the space shuttle configuration and to assess dynamic data developed after design are discussed. Examples are presented from the dynamic loads analysis of the lift-off and maximum dynamic pressure portion of ascent. Also shown are orbital flight test results, for which selected predicted responses are compared to measured data for the lift-off and high-dynamic-pressure times of ascent. These results have generally verified the design analysis. However, subscale testing was found to be deficient in predicting full-scale results in two areas: the ignition overpressure at lift-off and the aerodynamics/plume interactions at high-q boost. In these areas, the results of the flight test program were accommodated with no impact to the vehicle design

The Consistency of Rural Development Policies with the Position of the European Union on NTCS

The set of policy tools that the EU puts under the heading of Rural Development is extremely heterogeneous, such heterogeneity translates into a different degree of coupling support with agriculture production and also brings out the need to discuss the actual consistency of such tools with the UE position on NTCs at WTO. Examined in the present work are the Rural Development Plans (RDPs) and the Regional Operative Plans (ROPs) recently approved by the European Commission for the Italian Regions. The analysis is of a purely qualitative type and is based on currently available information, that is, the measures and the relative project typologies approved within the Plans. Taking into account the EU position on NTCs and their relation with multifunctionality we look at the tools applied for Rural Development in Italy with respect to their degree of de-coupling, production of externalities/non marketable goods and consistency with the EU position on NTCs. Financial allotment by measure typology is also examined. We found out that the present set of actions that fall under rural development is still dominated by a sector−based intervention, even in the case of measures aimed at safeguarding the environment, the least contestable ones. Paradoxically, the measures aimed at the promotion of Rural Development and at training, that better respond to the NTC objectives, are those for which the least resources are located.Non trade concerns, multifunctionality, rural development policies., Community/Rural/Urban Development,

Continuous versus discrete quantity discrimination in dune snail (Mollusca: Gastropoda) seeking thermal refuges

The ability of invertebrates to discriminate quantities is poorly studied, and it is unknown whether other phyla possess the same richness and sophistication of quantification mechanisms observed in vertebrates. The dune snail, Theba pisana, occupies a harsh habitat characterised by sparse vegetation and diurnal soil temperatures well above the thermal tolerance of this species. To survive, a snail must locate and climb one of the rare tall herbs each dawn and spend the daytime hours in an elevated refuge position. Based on their ecology, we predicted that dune snails would prefer larger to smaller groups of refuges. We simulated shelter choice under controlled laboratory conditions. Snails’ acuity in discriminating quantity of shelters was comparable to that of mammals and birds, reaching the 4 versus 5 item discrimination, suggesting that natural selection could drive the evolution of advanced cognitive abilities even in small-brained animals if these functions have a high survival value. In a subsequent series of experiments, we investigated whether snails used numerical information or based their decisions upon continuous quantities, such as cumulative surface, density or convex hull, which co-varies with number. Though our results tend to underplay the role of these continuous cues, behavioural data alone are insufficient to determine if dune snails were using numerical information, leaving open the question of whether gastropod molluscans possess elementary abilities for numerical processing

Hot Quark Matter with an Axial Chemical Potential

We analyze the phase diagram of hot quark matter in presence of an axial chemical potential, $\mu_5$. The latter is introduced to mimic the chirality transitions induced, in hot Quantum Chromodynamics, by the strong sphaleron configurations. In particular, we study the curvature of the critical line at small $\mu_5$, the effects of a finite quark mass and of a vector interaction. Moreover, we build the mixed phase at the first order phase transition line, and draw the phase diagram in the chiral density and temperature plane. We finally compute the full topological susceptibility in presence of a background of topological charge.Comment: 12 pages, 7 figures. Few references added, short discussion included. Final version appearing on Phys. Rev.

Reinforcement effectiveness on mechanical performances of composites obtained by powder bed fusion

New material formulations to be used in Additive Manufacturing machines are one of the major interests in this fast growing field. The possibility to tune functional and mechanical properties, by the addition of reinforcements to a polymeric matrix, is hindered by the low provisional capability of the additive manufactured composite. The inherent anisotropy of layer manufacturing combines with mechanisms of filler dispersion and of filler/matrix adhesion in a complex scenario. The paper entails a critical evaluation of mechanical properties measured for several polymeric composites produced by Powder Bed Fusion, in the perspective of provisional models commonly accepted for composite materials. The models are reviewed versus experimental and literature data. The provisional effectiveness is generally good, except for the case of nanometric or surface treated fillers, or of specific anisotropic microstructures obtained by layer manufacturing

Peptide self‐assembled nanostructures: from models to therapeutic peptides

: Self-assembly is the most suitable approach to obtaining peptide-based materials on the nano- and mesoscopic scales. Applications span from peptide drugs for personalized therapy to light harvesting and electron conductive media for solar energy production and bioelectronics, respectively. In this study, we will discuss the self-assembly of selected model and bioactive peptides, in particular reviewing our recent work on the formation of peptide architectures of nano- and mesoscopic size in solution and on solid substrates. The hierarchical and cooperative characters of peptide self-assembly will be highlighted, focusing on the structural and dynamical properties of the peptide building blocks and on the nature of the intermolecular interactions driving the aggregation phenomena in a given environment. These results will pave the way for the understanding of the still-debated mechanism of action of an antimicrobial peptide (trichogin GA IV) and the pharmacokinetic properties of a peptide drug (semaglutide) currently in use for the therapy of type-II diabetes

Repercussions of powder contamination on the fatigue life of additive manufactured maraging steel

A wide range of materials is suitable for processing by powder bed fusion (PBF) techniques. Among the latest formulations, maraging steel 18Ni-300, which is a martensite-hardenable alloy, is often used when both high fracture toughness and high strength are required, or if dimensional changes need to be minimised. In direct tooling, 18Ni-300 can be successfully employed in numerous applications, for example in the production of dies for injection moulding and for casting of aluminium alloys; moreover, it is particularly valuable for high-performance engineering parts. Even though bibliographic data are available on the effects that parameters, employed in PBF processes, have on the obtained density, roughness, hardness and microstructure of 18Ni-300, there is still a lack of knowledge on the fatigue life of PBF manufactured parts. This paper describes the fatigue behaviour of 18Ni-300 steel manufactured by PBF, as compared by forging. Relevant negative effects of the cross-contamination of the raw material are originally identified in this paper, which emphasizes the inadequacy of current acceptability protocols for PBF powders. In the absence of contamination, endurance achieved by PBF is found equal to that by forging and consistent with tooling requirements as set out by industrial partners, based on injection moulding process modelling

Beads for Cell Immobilization: Comparison of Alternative Additive Manufacturing Techniques

The attachment or entrapment of microbial cells and enzymes are promising solutions for various industrial applications. When the traps are beads, they are dispersed in a fluidized bed in a vessel where a pump guarantees fresh liquid inflow and waste outflow without washing out the cells. Scientific papers report numerous types of cell entrapment, but most of their applications remain at the laboratory level. In the present research, rigid polymer beads were manufactured by two different additive manufacturing (AM) techniques in order to verify the economy, reusability, and stability of the traps, with a view toward a straightforward industrial application. The proposed solutions allowed for overcoming some of the drawbacks of traditional manufacturing solutions, such as the limited mechanical stability of gel traps, and they guaranteed the possibility of producing parts of constant quality with purposely designed exchange surfaces, which are unfeasible when using conventional processes. AM proved to be a viable manufacturing solution for beads with complex shapes of two different size ranges. A deep insight into the production and characteristics of beads manufactured by AM is provided. The paper provides biotechnologists with a manufacturing perspective, and the results can be directly applied to transit from the laboratory to the industrial scale

The use of complementary and alternative medicine among california adults with and without cancer.

This article examines the extent and correlates of complementary and alternative medicine (CAM) use among a population-based sample of California adults that is highly diverse in terms of sociodemographic characteristics and health status. As a follow-up to a state-wide health survey of 55,428 people, 9187 respondents were interviewed by phone regarding their use of 11 different types of CAM providers, special diets, dietary supplements, mind-body interventions, self-prayer and support groups. The sample included all participants in the initial survey who reported a diagnosis of cancer, all the non-white respondents, as well as a random sample of all the white respondents. The relation of CAM use to the respondents' demographic characteristics and health status is assessed. CAM use among Californians is generally high, and the demographic factors associated with high rates of CAM use are the same in California as have been found in other studies. Those reporting a diagnosis of cancer and those who report other chronic health problems indicate a similar level of visits to CAM providers. However, those with cancer are less likely to report using special diets, and more likely to report using support groups and prayer. Health status, gender, ethnicity and education have an independent impact upon CAM use among those who are healthy as well as those who report suffering from chronic health problems, although the precise relation varies by the type of CAM used